According to a study presented at the European Association for the Study of Diabetes (EASD) 2018 Annual Meeting, the use of low-calorie sweetener capsules altered the gut microbiota in favor of the pathogenic bacteria compared to the capsules used on the placebo group. Another aspect of the study was the fact that consuming sweeteners were related to the increase of bad bacteria and the decrease of the good ones. This disruption in gut balance leads to certain metabolic consequences that are harmful to the consumer. 

Researchers found that after 2 weeks of supplementation, the experimental group showed increase glucose absorption and glycemic response while the response to glucagon production decreased thereby altering glucose metabolism. This means more sugar isn’t absorbed while the mechanism regulating sugar metabolism is disrupted. Due to this finding, experts say that the use of low-calorie sweeteners can actually interact with the effects of diabetes medication making them less effective in the long run.

However long-term data is still not present to make a conclusive interpretation as of the moment. Experts now believe that the use of low-calorie sweeteners should be in moderation as it has been shown to have negative effects as well as a positive effect on weight control.

European Association for the Study of Diabetes (EASD) 2018 Annual Meeting

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https://www.medscape.com/viewcollection/34642