Sterile procedure setup in the image-guided suite at Padda Institute, St. Louis

Peripheral nerve stimulation · St. Louis

Peripheral Nerve Stimulation in St. Louis

Targeted neuromodulation of a single damaged or irritated nerve outside the spinal cord, for focal pain that has not responded to injections.

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Same-day and emergency appointments are available.

What does peripheral nerve stimulation treat?

Where spinal cord stimulation addresses pain across a broad region, peripheral nerve stimulation targets one nerve. It suits focal pain that can be traced to a specific nerve: pain after a nerve injury, entrapment that persists after decompression, or a painful nerve in the shoulder, knee, foot or trunk. The more precisely the pain maps to one nerve, the better this approach tends to work.

Identifying the right nerve

Precision matters more here than in almost any other procedure we offer. Electrodiagnostic testing and diagnostic nerve blocks are used to confirm which nerve is generating the pain before any lead is placed. A block that reliably abolishes the pain is strong evidence that stimulating that nerve will help.

How is a peripheral nerve stimulator placed?

A fine lead is positioned alongside the target nerve under image guidance. We use both ultrasound and fluoroscopy, and prefer fluoroscopy where it is available: ultrasound shows the nerve, the surrounding vessels and the lead in real time as it is advanced, while fluoroscopy documents the final lead position against the bony landmarks, which is the record any later check or revision is read against. Because no sedation is used, your feedback during placement guides where the lead ends up. As with spinal cord stimulation, a trial period precedes any permanent system.

What happens during a peripheral nerve stimulator procedure?

The procedure is performed awake and on an outpatient basis, usually taking under an hour. Some systems are designed as a fixed-duration treatment lasting weeks rather than a permanent implant, which suits patients who want to avoid a long-term device. We discuss which category fits your situation before scheduling.

How does peripheral nerve stimulation work?

Peripheral nerve stimulation works on the same principle as spinal cord stimulation but applies it closer to the source. Electrical current preferentially recruits large-diameter myelinated fibers, which have a lower activation threshold than the small unmyelinated C fibers carrying most chronic pain traffic. Activating those large fibers drives inhibitory interneurons in the dorsal horn and suppresses transmission from the smaller ones.

Because the lead sits next to one identified nerve rather than the spinal cord, the effect is confined to that nerve territory. That is a limitation when pain is diffuse, and an advantage when it is not: there is no need to place hardware in the epidural space to treat a single entrapped nerve in a limb.

Temporary systems and what the trials show

An important development is the sixty-day percutaneous system. A fine lead is placed, worn for up to sixty days, then withdrawn, with no permanent implant left behind. The rationale is that sustained modulation may reset the sensitized circuit rather than simply masking the signal while the device runs.

Published prospective work supports durable relief in a meaningful proportion of patients after the lead is removed, and the RESET trial met its primary endpoint, with more patients achieving at least fifty percent pain relief at three months than those receiving standard interventional care. The evidence base is younger and smaller than for spinal cord stimulation, and we present it that way rather than as settled.

Auricular vagal stimulation for diabetic peripheral neuropathy

For painful diabetic peripheral neuropathy we use the NS-100, a programmable peripheral electrical nerve stimulator manufactured by Nalu. It is an FDA-cleared Class II device.

It is applied to the auricular branches — the nerve branches at the ear — rather than to the nerves in the painful limb, and it acts as a vagal stimulator. That is the part patients find counter-intuitive: the device is placed at the ear and the pain being treated is in the feet. It works through the vagal pathway and its influence on how pain signals are processed, not by interrupting the painful nerve where it hurts.

The stimulator is worn for a defined period — up to 30 days, though most patients are treated for around 20. Nothing is left permanently in place.

Placement is done under local anesthetic with no sedation, you drive yourself home, and there are no activity restrictions afterward.

On coverage. Peripheral nerve stimulation is a covered category under Medicare’s national coverage determination for electrical nerve stimulators, and local coverage determinations set the criteria that apply. That is the category, not a promise about your claim: your specific plan, indication and documentation still govern, so coverage is verified before anything is scheduled. An authorization, where one is obtained, is not itself a guarantee of payment.

See diabetic peripheral neuropathy for how the condition is evaluated before this point is reached.

What Our Patients Say

Individual results vary. These are unpaid patient testimonials shared with permission and are not a guarantee of outcome. See all patient stories.

Frequently Asked Questions

Spinal cord stimulation treats a broad region through leads near the spinal cord. Peripheral nerve stimulation treats one specific nerve, with the lead placed near that nerve in the limb or trunk.

Yes. As with spinal cord stimulation, a trial establishes whether the response justifies a permanent system.

Yes. It is frequently combined with rehabilitation and medication adjustment, and it does not preclude other procedures later.

The evidence is encouraging but younger and smaller than it is for spinal cord stimulation, and we present it that way. In the RESET trial, more patients reached at least fifty percent pain relief at three months than patients receiving standard interventional care. Your own odds depend most on precision: a diagnostic block that reliably stops your pain is strong evidence that stimulating that nerve will help.

It is a small electrical system that treats pain carried by one nerve. A fine lead is placed next to that nerve under image guidance and delivers impulses that change the pain signal the nerve sends. Some systems become permanent after a trial. Others, such as the sixty-day percutaneous system, are worn for a set period and then withdrawn, leaving nothing behind.

Peripheral nerve stimulation is a covered category under Medicare's national coverage determination for electrical nerve stimulators, and local coverage determinations set the criteria. That is the category, not a promise about your claim. Your plan, your diagnosis and your documentation still decide it, so we verify coverage before anything is scheduled. An authorization is not itself a guarantee of payment.

For painful diabetic peripheral neuropathy we use the NS-100, an FDA-cleared stimulator placed at the ear rather than on the feet. It works through the vagal pathway and its influence on how pain signals are processed. It is worn for up to 30 days, most patients around 20, and nothing stays in place. Placement uses local anesthetic with no sedation, and you drive yourself home.

Request an Appointment

Same-day and emergency appointments are available. Call (314) 481-5000 or request a time below.

Prefer not to fill in a form?

Same-day and emergency appointments are available.

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